| 摘要 |
<p>The present invention relates to new tetralones having the formula I: <CHEM> wherein: R<1> and R<2> represent hydrogen, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, pentafluoroethyl, ethynyl, trimethylsilylethynyl, C1-4 alkylcarbonylamino being the amino optionally substituted by a C1-4 alkyl group; R<3> is hydrogen or C1-4 alkyl, and R<4> is C1-4 alkyl, or R<3> and R<4> together form a C2-5 polymethylene chain; either R<5> represents hydroxyl, acetoxy or formyloxy and R<6> and R<7> are both hydrogen, or R<5> together with R<6> form a carbonyl group and R<7> hydrogen, or R<5> and R<7> together form a bond and R<6> is hydrogen; R<8> is, among others, 1,2-dihydro-2-oxo-1-pyridyl, 2,3-dihydro-1-oxo-1H-isoindol-2-yl, 2-oxo-1-pyrrolidinyl, 2-oxo-1-pyperidinyl. The invention also relates to a procedure for their preparation and to pharmaceutical compositions containing them. These compounds are antihypertensive and bronchodilator agents.</p> |
