发明名称 |
PHOTODYNAMIC INACTIVATION OF VIRUSES IN BLOOD CELL-CONTAINING COMPOSITIONS |
摘要 |
The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1 X 10<9> cells/ml and said virus without incurring substantial disruption or inactivation of such cells, the inactivation process comprising contacting the composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of >/= 630 nm, light and an oxidizer, thereby substantially to inactivate the virus with retention of cell functionality, greater than 80%. The present invention also concerns the product produced by inactivating virus in a biological composition without incurring substantial disruption or inactivation thereof, the inactivation process comprising contacting said composition with a virucidally effective amount of at least one photoreactive compound, light, and a quencher thereby to inactivate said virus while retaining functionality of said substance. <IMAGE>
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申请公布号 |
US5120649(A) |
申请公布日期 |
1992.06.09 |
申请号 |
US19900524208 |
申请日期 |
1990.05.15 |
申请人 |
NEW YORK BLOOD CENTER, INC. |
发明人 |
HOROWITZ, BERNARD;VALINSKY, JAY E.;GEACINTOV, NICHOLAS E.;WILLIAMS, BOLANLE;RYWKIN, SHANTI B. |
分类号 |
A61K31/35;A61K31/555;A61K35/14;A61K41/00;A61L2/00;C12N7/04;C12N7/06 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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