发明名称 |
IMIDOESTER CROSS-LINKED HEMOGLOBIN COMPOSITIONS |
摘要 |
2093650 9209630 PCTABS00013 An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mM Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.
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申请公布号 |
CA2093650(A1) |
申请公布日期 |
1992.05.30 |
申请号 |
CA19912093650 |
申请日期 |
1991.10.03 |
申请人 |
UPJOHN COMPANY (THE) |
发明人 |
GARLICK, ROBERT L.;MARTIN, JOSEPH P., JR.;LYLE, STEPHEN B. |
分类号 |
A61K38/16;A61K38/00;C07K1/107;C07K1/14;C07K14/00;C07K14/805;(IPC1-7):A61K38/42;A61K35/18 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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