| 摘要 |
A method for producing glycine amide hydrochloride distinctive in that chloroacetamide is amonolised in an aqueous ammonia solution in the presence of equimolar amount of amone hydrocarbon in the temperature of 30-40 degrees C, preferably 30-35 degrees C; the post-reaction mixture is cooled down to ambient temperature and then further chilled to the level of +5 to -5 degrees C; while being intensely stirred the mixture is supplemented with 5 moles of HCl in the temperature of 0-5 degrees C in anticipation of receiving 1 mole of chloroacetamide in the form of concentrated hydrochloric acid; then crystallised amone chloride is separated from the mixture through the process of filtration; the filter is evaporated under lowered pressure in the temperature of 50 degrees C and the dry deposit left on it is poured over with 3.48 dm<3> of boiling acetic acid in anticipation of receiving 1 mole of a basic substrate; then again, crystallised amone chloride is separated in hot conditions and the filter cooled down to the temperature of 15-20 degrees C and left alone for 10-15 hours until glycine amide hydrochloride is crystallised; the product thus crystallised is separated by way of filtration; another batch of the product is separated from the mother lye through condensation and crystallisation; then the product is recrystallized from ethanol and post-crystallisation lye is returned to the process, combined with the basic stream and treated with boiling acetic acid.
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