| 摘要 |
PURPOSE:To obtain the titled compound economically and easily, in high yield and purity, by reacting 5-fluorouracil with 2,3-dihydrofuran in pyridine in the presence of a carboxylic acid, and treating the obtained reaction liquid with an aqueous solution of a carboxylic acid salt. CONSTITUTION:The objective compound of formula III can be prepared by reacting 5-fluorouracil of formula I with 2,3-dihydrofuran of formula II in the presence of a carboxylic acid such as lower aliphatic carboxylic acid at 80-180 deg.C, adding an aqueous solution of a carboxylic acid salt such as an alkali metal or alkaline earth metal salt of a <=8C carboxylic acid to the reaction solution, and treating at a temperature between room temperature and 100 deg.C. The amount of the carboxylic acid is 0.1-2.5mol per 1mol of the compound of formula I, and the concentration of the aqueous solution of carobxylic acid salt is 0.01-10mol. EFFECT:The carboxylic acid salt acts also as a salting-out agent in the extraction of the reaction product to improve the extraction efficiency. USE:Antitumor agent, antiviral agent, etc. |
