| 摘要 |
<p>Disclosed are monoclonal antibodies and related products including mAb fragments and mAb-toxin conjugates, which are associated with membrane-bound immunoglobulins, such as the IgD-α or IgM-α proteins. Also disclosed are anti-idiotype antibodies and peptides which induce production of antibodies which target such proteins, and the use of such mAbs and related products in suppression or depletion of B cells. Targeting IgD-α or IgM-α can be used to suppress or deplete activated or resting B cells. Uses in causing immunosuppression, treating autoimmune diseases, and enhancing the immune response against particular antigens are also disclosed.</p> |
