99 MTC (III) MYOCARDIAL IMAGING AGENTS WHICH ARE NON-REDUCABLE IN VIVO

摘要

99mTc(III) MYOCARDIAL IMAGING AGENTS WHICH ARE NON-REDUCABLE IN VIVO A cationic 99mTcIII myocardial imaging agent: is disclosed which has a relatively negative redox potential. Thiq prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the Tc(III) is controlled by complexing the Tc with both hard and soft atoms. Preferably four of the atoms complexed to the Tc(III) are hard atoms such as nitrogen or oxygen and the remaining two are soft atoms such as phosphorous or arsenic. These imaging agents are particularly useful in imaging the human heart.