发明名称 |
Derivatives of soluble T-4 |
摘要 |
This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185. This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
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申请公布号 |
US5110906(A) |
申请公布日期 |
1992.05.05 |
申请号 |
US19880160348 |
申请日期 |
1988.02.24 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;SMITHKLINE BECKMAN CORPORATION |
发明人 |
MADDON, PAUL J.;AXEL, RICHARD;SWEET, RAYMOND W.;ARTHOS, JAMES |
分类号 |
C12N15/09;A61K38/00;A61P31/12;C07K14/00;C07K14/725;C07K14/73;C07K16/28;C12N5/10;C12P21/02;C12Q1/70;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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