发明名称 |
PROCESS FOR PREPARING A RADIOPHARMACEUTICAL COMPOSITION |
摘要 |
A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH2CO-NHCH2CO-NHCH2CO-NHCH2COOH (mercaptoacetylglycylglycylglycine, MAG3), (b), a water-soluble reducing agent, (c) a water-soluble stabilizing agent in an amount of not less than 70 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11; and (2) heating the resultant mixture at a temperature of about 90 to 140.degree.C. This process removes any troublesome labelling operation at the diagnostic site and hence relieves practitioners from exposure to radiation during the labelling operation.
|
申请公布号 |
CA2054263(A1) |
申请公布日期 |
1992.05.01 |
申请号 |
CA19912054263 |
申请日期 |
1991.10.25 |
申请人 |
KONDO, SUSUMU;OKANO, SAKAE;AZUMA, MAKOTO |
发明人 |
KONDO, SUSUMU;OKANO, SAKAE;AZUMA, MAKOTO |
分类号 |
A61K51/00;A61K51/08;C07F13/00;(IPC1-7):A61K49/02 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|