发明名称 2-PHENYL-AND 2-THIENYL-(2)-PIPERIDINE DERIVATIVES HAVING NEUROPROTECTIVE PROPERTIES
摘要 Compounds of formula (I) in which R1 and R2, which may be the same or different, represent hydrogen or C1-6 alkyl, R3 and R4 independently represent one or more radicals selected from hydrogen, NH2, NO2, halogen, hydroxyl, C1-6 alkoxy or C1-6 alkyl, X represents S or a -CH=CH- group, and pharmaceutically acceptable derivatives thereof are useful as pharmaceuticals, in particular they possess N-methyl-(d)-aspartate (NMDA) blocking properties and are useful in the treatment and/or prevention of neurological disorders.
申请公布号 WO9206957(A1) 申请公布日期 1992.04.30
申请号 WO1991US07522 申请日期 1991.10.11
申请人 FISONS CORPORATION 发明人 GRIFFITH, RONALD, CONRAD;SCHMIESING, RICHARD, JOHN;MURRAY, ROBERT, JOHN
分类号 A61K31/445;A61K31/4433;A61K31/4458;A61K31/451;A61P9/00;A61P9/08;A61P9/10;A61P25/00;A61P25/08;A61P25/14;A61P25/28;C07D211/12;C07D211/14;C07D211/18;C07D211/22;C07D211/26;C07D211/70;C07D211/76;C07D409/04 主分类号 A61K31/445
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