FREMGANGSMAADE TIL FREMSTILLING AF EN PERAPEUTISK AKTIV AMIN

摘要

A process for the preparation of the therapeutically active 1-isopropylamino-3-[4-(2-methoxyethyl)phenoxy]-2-propanol of the formula comprising the reaction of 1,2-epoxy-3-[4-(1-acetoxy-2-methoxy-ethyl)phenoxy]-propane with isopropylamine yielding 1-isopropylamino-3-[4- (1-acetoxy-2-methoxyethyl)phenoxy]-2-propanol, which is reduced either by catalytic hydrogenolysis or with sodium borohydride in an inert solvent containing trifluoroacetic acid or methanesulfonic acid to a compound of formula (I).