| 摘要 |
PCT No. PCT/GB89/00996 Sec. 371 Date Feb. 22, 1991 Sec. 102(e) Date Feb. 22, 1991 PCT Filed Aug. 25, 1989 PCT Pub. No. WO90/01987 PCT Pub. Date Mar. 8, 1990.In carrying out an organic chemical reaction, such as the synthesis of a polypetide, it is known to attach a substance to particles of pervious support material and to immerse the particles in a sequence of liquids which serve as reagents, solvents etc. The invention provides a method in which, during at least one stage in a reaction of that kind, a liquid is introduced into a vessel containing particles of support material in such a manner that the immediately preceding liquid is progressively displaced by the incoming liquid. Apparatus for carrying out that method comprises a vessel (1) with upper and lower sintered restraining plates (5 and 6) between which the support material is located. Valves (8 and 11) can be set at will to enable a pump (13) to pump liquid into the vessel from above or below and to recirculate or discharge the liquid.
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