| 摘要 |
There are disclosed compounds of the formula <IMAGE> wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, <IMAGE> W is -CR2O-, -CH=CH- or -CH=CHCH2O- X is N or CR; Z is <IMAGE> R is hydrogen or lower alkyl; Y is <IMAGE> <IMAGE> R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring, optionally substituted by halo; R3 is -OR, <IMAGE> - NHSO2R4; R4 is phenyl or loweralkyl substituted phenyl; R5 is halo; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as alelrgic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions. |
