摘要 |
PCT No. PCT/GB91/01543 Sec. 371 Date May 10, 1993 Sec. 102(e) Date May 10, 1993 PCT Filed Sep. 10, 1991 PCT Pub. No. WO92/04331 PCT Pub. Date Mar. 19, 1992. <IMAGE> (I) Substituted 4,5-diaryl-2-imidazolones of structure (I), in which each group AR is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R1 is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; n is 4 to 12; and X is 5-tetrazolyl, SO3H, P(O)(OR)2, P(O)(OH)2 or P(O)(R)(OR) in which R is hydrogen acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders. |