| 摘要 |
NEW MATERIAL:The antibiotic substance TAN-528B of formula having the following characteristics. Apperance, orange yellow crystalline powder; meting point, 170-175 deg.C (decomposition); specific rotation, [alpha]<27>$D-32 deg.+ or -5 deg. (C=0.10, in chloroform); elemental analysis (%), C 59.86, H 6.48, N 1.98, S 3.52; molecular formla, C37H47NO13S; molecular weight, 745.84; solubility, easily soluble in ace tone, ethyl acetate, dichloro-methane, and dimethyl sulfoxide, ahrdly soluble in water and hexane; color reaction, positive to Barton reaction and magnesium acetate reaction, negative to ninhydrin reaction, Dragendorff reaction, etc.; etc. USE:Antibafterial agent effective mainly to Gram-positive bacterial and applicable by oral administration. PREPARATION:Streptomyces albolongus CM-11 strain (FERM P-7877) is cultured preferably in a liquid medium by submerged technique at 6-8 pH and 17-30 deg.C for 24-72hr. |
