| 摘要 |
2067798 9205810 PCTABS00011 Novel hydrogel formulations useful as adhesive reservoirs for topical or transdermal drugs employ as the polymer base a crosslinked polymer or copolymer of 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof. The gels are prepared from polymerizable compositions comprising: 20 % - 50 % of a monofunctional monomer component, at least 75 % of said component comprising 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof, the balance being selected from the group consisting of acrylic acid, water soluble acrylic functional monomers and vinyl pyrrolidone; 30 % - 50 % of a glycol component selected from the group consisting of compounds of the formula: HO-(C2H4O)n-H, HO-(C3H6O)m-H and mixtures thereof, where n is in the range of about 4 to about 16 and m is 1-4; between about 0.02 % and about 0.20 % of a crosslinking monomer; an amount of a free radical polymerization initiator effective for initiating polymerization of said monofunctional monomer and crosslinking monomer components; and a therapeutically effective amount of a topically or transdermally deliverable drug, at least about 60 % of said drug being dissolved in the formulation.
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