发明名称 |
SYNTHETIC POLY-IG RECEPTOR,RECEPTOR-ANTIBODY COMPLEXES,PRODUCTION AND USE THEREOF |
摘要 |
Poly-Ig antibodies (particularly monoclonal IgA's) are complexed with a stabilizer protein derived from the poly-Ig receptor (partricularly a recombinant receptor-derived stabilizer protein), which includes at least one poly-Ig binding domain of the receptor, and substantially lacks any C-terminal transmembrane or intracellular poly-Ig receptor domains. The stabilized complex can be used as a passive vaccine administration to mucosal surfaces. Methods for in vivo screening of monoclonal poly-Ig are also disclosed. Methods of generating the complex using a monolayer of anchorage-denpendent epithelial cells engineered to make poly-Ig receptor are also disclosed. Hybridomas for manufacture of monoclonal IgA, are made by harvesting lymphoid cells from mucosal tissue (e.g. Peyer's patches) rich in such cells. |
申请公布号 |
ZA9102837(B) |
申请公布日期 |
1992.03.25 |
申请号 |
ZA19910002837 |
申请日期 |
1991.04.16 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;INSTITUT SWISSE DE RECHERCHES EXPERTMENTALES SUR LE CANCER |
发明人 |
JEAN-PIERRE KRAEHENBUHL;RICHARD A. WELTZIN;MARIAN R. NEUTRA |
分类号 |
A61K39/395;A61K;C07K;C07K1/113;C07K14/00;C07K14/03;C07K14/15;C07K14/155;C07K14/195;C07K14/37;C07K14/41;C07K14/435;C07K14/705;C07K16/00;C07K16/08;C07K16/12;C07K16/28;C07K19/00;C12N5/00;C12N15/09;C12N15/13;C12P21/00;C12P21/08;C12R1/91;G01N33/53;G01N33/569;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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