摘要 |
A compound of the formula (I): <IMAGE> wherein R is C2-10 alkyl, alkenyl or alkynyl, each optionally subsituted by or methyl substituted by cyano, C3-4 cycloalkyl, halo, C1-4 alkoxy or a group S(O)mR4 where R4 is C1-4 alkyl and m is O, 1 or 2, or R is C3-10 cycloalkyl, C4-10 cycloalkenyl or phenyl, each optionally substituted by C1-4 alkoxy, C1-3 alkyl, C2-4 alkynyl, halo, cyano or a group S(O)mR4 as defined hereinbefore; R1 is halo, C1-3 alkyl, C2-3 alkenyl or alkynyl each optionally substituted by halo, cyano, C1-4 alkoxy, alkyl carbalkoxy containing up to 6 carbon atoms, a group S(O)mR4 as defined hereinbefore or alkynyl substituted by tri-C1-4 alkylsilyl, or R1 is cyano, spiro-cyclopropyl, gem dimethyl, oxo or methylene optionally substituted by cyano or C1-3 alkyl optionally substituted by fluorine, or R1 and R and the carbon atoms to which they are attached form a C5-7 carbocyclic ring optionally substituted by halo, C1-3 alkyl or alkoxy or C 2-3 alkenyl, R2 is phenyl, C5-10 cycloalkyl or cycloalkenyl each optionally substituted other than phenyl substituted by C2-3 alkynyl and R3 is hydrogen, C1-3 alkyl, C2-3 alkenyl or alkynyl each optionally substituted by cyano, C1-4 alkylthio, C1-4 alkoxy or halo, or R3 is cyano, its use in medicine, pharmaceutical compositions containing it and processes for its preparation.
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