| 摘要 |
The invention relates to novel polycyclic derivatives of rifamycins of the formula <CHEM> and the salts thereof, in which the structural elements -A1-A2-, -A3-A4- and -A5-A6- each denote ethylene or vinylene or the elements -A1-A2 and -A3-A4- each denote ethylene and -A5-A6- denotes vinylene; X represents <CHEM> Or <CHEM> and R6 denotes hydrogen or alkyl; A denotes a bond, a bivalent aliphatic hydrocarbon radical or, if X represents <CHEM> represents the structural element -X1-A1- in which X1 denotes -O-, -S(O)n- or -N(R6)- n being 0, 1 or 2 and R6 being hydrogen or alkyl and in which A1 denotes a bivalent aliphatic hydrocarbon radical; R1 denotes hydrogen or acyl; R2 denotes acyl or an aliphatic radical; and R3 and R3 min represent a common bond; or R3 denotes hydrogen, acyl or an aliphatic radical, and R3 min is hydrogen or an aliphatic radical; R4 denotes optionally substituted bicycloheptyl, bicycloheptenyl or adamantyl; R5 denotes hydrogen or acetyl;R7 denotes hydrogen or alkyl; the preparation and use thereof, and pharmaceutical products and the preparation thereof.
|
