| 摘要 |
Described are caffeic acid derivatives represented by the following formula: <CHEM> wherein either one of R<1> and R<2> is a hydrogen atom, a C1-C6 alkyl group, a group -CO2R<4>, or a group -CONR<5>R<6>, R<4>, R<5> and R<6> being either a hydrogen atom or a particular group, and the other is the group -CO2R<4> or the group -CONR<5>R<6>, or R<1> and R<2> are coupled together to represent a 5-membered ring so formed, Y represents a particular group or atom, X represents a substituted or unsubstituted C6-C10 aryl, C7-C12 aralkyl, heterocyclic or heterocyclic ring-alkyl group, m and n stand for particular integers, and R3 represents a hydrogen atom, a hydroxyl group, a group -OCO2R<7>, R<7> being a hydrogen atom or a particular group, or a group -OCONR<8>R<9>, R<8> representing a C1-C6 alkyl group and R<9> representing a hydrogen atom or a C1-C6 alkyl group, and pharmaceutically acceptable salts thereof. Therapeutic agents containing the derivatives or salts are effective for diseases of the circulatory system.
|
