ESTRAN- UND ANDROSTAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PRAEPARATE.

摘要

(A) Oestrane and andiostone derivs. of formula (I): X = Br or I (opt. radioactive), terphenylstannyl or tri(1-6C alkyl) stannyl; Y = H2 or CH2; Z = H2, O or 2-6C alkylenedioxy; Y = ethylene, vinylene, 1,3-propylene or cyclopropylene; R1 = H or a 1-8C hydrocarbon group opt. interrupted by an oxy group or substd. by an oxo group; R2 = CH3 or C2H5; R3 = H and R4 = H or CH3; or R3+R4 = C-C bond; asterisk 4(5) double bond when Z is H2, or a 5(10) double bond in an oestrane deriv. when Z is alkylenedioxy. (B) The followinq intermediates: 3,3-ethylenedioxy -17alpha-(2-tributylstannyl) vinyl)-5(10), 9(11)-oestradien -17beta-ol; 3,3-ethylenedioxy -17alpha-(2-iodovinyl)-5(10),9(11) oestradien-17beta-ol; 17alpha-(2-bromovinyl) 3,3-ethylenedioxy-5(10),9(11) -oestradien-17beta-ol; 17beta hydroxy-17alpha -(2-iodovinyl) -4,9-oestradien-3-one; and 17 alpha-(2-bromovinyl)-17beta hydroxy-4,9 -oestradien-3-one.