Process for iodinating or brominating the alpha-methylenic carbon of a secondary amide.

摘要

A novel, facile, and specific process for alpha -iodinating or alpha -brominating the alpha -methylenic carbon of a straight chain, branched chain, or cyclic secondary amide, such as a lactam or an azasteroid, comprises reacting the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methyl, ethyl, or n-propyl, in the presence of I2 or Br2. The alpha -iodo- or alpha -bromo-amide is useful for making the alpha , beta -unsaturated amide through dehydrohalogenation.