| 摘要 |
11-Haloprostane derivs. of formula (I) and their salts are new: X = F, Cl or Br; R1 = CH2OH, COOR2, 2-oxazolinyl, 5,5-dimethyl-1,3-dioxan-2-yl or CONHR3; R2 = H, alkyl, cycloalkyl, aryl, phenacyl or heterocyclyl; R3 = acyl or R2; A = CH2CH2 or cis-CH=CH; B = CH2CH2, trans-CH=CH or C=C; W = ethylenedioxy or opt. functionally modified CHOH; D = 1-10C alkylene opt. substd. by F; E = O, S, a bond, C=C or CR6=CR7; or D+E = a bond; R4 = opt. functionally modified OH; R5 = H, alkyl, methoxyalkyl, haloalkyl, cycloalkyl, opt. substd. aryl or heterocyclyl; R6 and R7 = H, Cl or alkyl.
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