发明名称 |
VERFAHREN ZUR HERSTELLUNG VON CEPHALOSPORINESTERN. |
摘要 |
<p>Cephalosporin esters of the formula <IMAGE> I wherein R2 is hydrogen or acyl and R1 is a group which is readily removable by hydrolysis, and pharmaceutically acceptable acid addition salts of basic compounds of formula I in which R2 is an acyl group, may be prepared by reacting 7-amino-3-methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bicyclic amidine of the formula <IMAGE> II wherein n is the integer 3, 4 or 5, and a halide of the formula X-R1 III wherein X is halogen and R1 has the above significance, if desired, treating the resulting compound of formula I in which R2 is hydrogen with an unprotected or optionally protected acylating agent, cleaving off a protecting group which may be present and, if desired, treating a resulting basic compound of formula I in which R2 is an acyl group into a pharmaceutically acceptable acid addition salt.</p> |
申请公布号 |
DE3585154(D1) |
申请公布日期 |
1992.02.20 |
申请号 |
DE19853585154 |
申请日期 |
1985.10.19 |
申请人 |
F. HOFFMANN-LA ROCHE AG, BASEL, CH |
发明人 |
FURLENMEIER, DR., ANDRE, CH-4058 BASEL, CH |
分类号 |
A61K31/545;C07D501/04;C07D501/18;C07D501/20;C07D501/22;(IPC1-7):C07D501/18 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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