| 摘要 |
This invention describes a process for obtaining new sulphoxides and sulphones of formula I, in which: R1 represents a C10-C24 alkyl, alkenyl or alkinyl group, R2 is a C1-C6 alkyl or alkoxy group, Z is -O-, -C(=O)- or -NR5C(=O)O-, where R5 is hydrogen, C1-C4 acyl or Z is a single bond, n is 1 or 2, q is 0 or 1, t is (+) when q = 1 and t has the value zero when q = 0, R3 is hydrogen or C1-C6 alkyl when q = 1 and is a pair of electrons when q = 0, A- is a pharmaceutically acceptable anion. The process comprises reacting a compound of formula II with one or two equivalents of an oxidizing species such as metachloroperbenzoic acid (MCPBA) to yield a compound of formula Ia. Optionally the compound may be reacted with a compound of formula R3Y (III) (where Y is halide, methyl sulphonate or p-toluene sulphonate) to yield a compound of formula Ib, and finally, if desired, the Y anion can be exchanged for another pharmaceutically acceptable anion A by ion exchange chromatography or selective salt precipitation. These compounds are PAF antagonists and are therefore useful in the treatment of diseases in which the said substance is implicated. <IMAGE>
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