| 发明名称 |
SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION |
| 摘要 |
2089376 9203568 PCTABS00011 Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of HIV, herpes virus, papillomavirus and other infections is provided.
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| 申请公布号 |
CA2089376(A1) |
申请公布日期 |
1992.02.14 |
| 申请号 |
CA19912089376 |
申请日期 |
1991.08.12 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP D.;KAWASAKI, ANDREW M. |
| 分类号 |
A61K31/70;A61K31/7088;A61K38/00;A61K48/00;A61P31/12;A61P31/22;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/00;C07H21/04;C07H23/00;C07J43/00;C12N9/02;C12N15/09;C12N15/113;C12P21/00;C12Q1/68;(IPC1-7):C07H21/00;C07H19/173 |
主分类号 |
A61K31/70 |
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