HEPARIN SUSTAINED RELEASE MATERIAL AND PRODUCTION THEREOF

摘要

PURPOSE:To obtain the title material suitable for such medical products as to be in contact with the blood for a long period of time by introducing tertiary amino group into the side chain of a PVA-based polymer followed by mixing with heparin in its solution state and then forming into a hydrogel. CONSTITUTION:A compound having in the molecule both tertiary amino and aldehyde groups (e.g. p-dimethylaminobenzaldehyde) is reacted with a PVA-based polymer to prepare a solution of a PVA-based polymer with tertiary amino group in its side chain. Heparin is then added to this solution followed by neutralization with pref. an alkali to adjust the pH of the solution to >=2. Thence, the resulting solution is either formed or applied on the surface of a base material followed by solidification into a hydrogel, thus giving the objective heparin sustained release material. With this method, the present material with a large amount of heparin carried within can be obtained. Formation of ionic bond in the present material will result in the slower release of the heparin, thus maintaining anti-thrombogenicity for a long period of time.