BONT/E OR SNAP-25E FOR TREATING BOTULINUM TOXIN A OR C1 POISONING AND INHIBITING MUSCLE CONTRACTION

摘要

A method for treating a patient with Botulinum toxin A (BoNT/A) or Botulinum toxin C1 (BoNT/C1) poisoning, wherein the patient is administered Botulinum toxin E (BoNT/E) or a polynucleotide encoding and capable of expressing BoNT/E, or a fragment derivable by cleavage of synaptosomal-associated polypeptide of 25 kDa (SNAP-25) or a variant thereof by BoNT/E (SNAP-25E) or a polynucleotide encoding and capable of expressing SNAP-25E. The patient may have botulism acquired naturally or accidentally, or may have been injected with BoNT/A or BoNT/C1 for medical purposes. A method for treating a patient in need of short duration inhibition of exocytosis in a cell of the patient, wherein the patient is administered BoNT/E or a polynucleotide encoding and capable of expressing BoNT/E, or a fragment derivable by cleavage of synaptosomal-associated polypeptide of 25 kDa (SNAP-25) or a variant thereof by BoNT/E (SNAP-25E) or a polynucleotide encoding and capable of expressing SNAP-25E and is not administered BoNT/A, B, C, F or G. The patient may be in need of inhibition of exocytosis of less than 14 days' duration.