| 摘要 |
The compounds of the formula <IMAGE> I wherein X and Y are independently -CH2- or >C(CH3)2; Z is -CHR8-, >CO, >CR8OR7, -CHR8-CHR8-, -CHOR7-CH2-, -CO-CHOR7 or -CHOR7-CHOR7-; R1 is a 5- or 6-membered, monocyclic heterocyclic group which optionally can be C-substituted by halogen, lower-alkyl, lower-alkoxy, acyloxy, nitro, hydroxy, amino, lower-alkylamino or di-lower-alkylamino and/or which can be substituted on a ring -NH- group by lower-alkyl; R2 and R3 are independently hydrogen, lower-alkyl, trifluoromethyl or halogen and one of R2 and R3 always is trifluoromethyl or lower-alkyl; R4 and R5 are independently hydrogen, alkyl, alkoxy or halogen; R6 is hydrogen, lower-alkyl or -OR7; R7 is hydrogen, lower-alkyl or acyl; R8 is hydrogen or lower-alkyl; and R7 and R8 can be the same or different from one another, are useful for the treatment of neoplasms and dermatoses in mammals. The compounds can be manufactured from a corresponding bicyclic component and a heterocyclic component containing the residue R1 by a Wittig, Horner or Grignard reaction and the optional subsequent transformation of reactive groups.
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