| 发明名称 |
MODIFIED EGLIN PROTEINS |
| 摘要 |
Novel elgin mutants that differ from the natural eglins B and C by the replacement of one, two or three amino acids in the region of the active center (amino acids 45 and 46, Leu-Asp) by other amino acids are provided. The mutants, which can be produced by recombinant genetic engineering, have valuable pharmacological properties.
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| 申请公布号 |
US5079229(A) |
申请公布日期 |
1992.01.07 |
| 申请号 |
US19890320139 |
申请日期 |
1989.03.07 |
| 申请人 |
CIBA-GEIGY CORPORATION |
发明人 |
GRUETTER, MARKUS G.;HEINZ, DIRK;LIERSCH, MANFRED |
| 分类号 |
C12N9/99;A61K38/00;A61K38/55;A61P1/00;A61P9/00;A61P11/00;A61P29/00;C07K14/00;C07K14/81;C07K14/815;C12N1/19;C12N1/21;C12N15/09;C12N15/15;C12N15/81;C12N15/82;C12P21/02;C12R1/125;C12R1/19;C12R1/865 |
主分类号 |
C12N9/99 |
| 代理机构 |
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