CDR GRAFTED ANTI-CEA ANTIBODIES AND THEIR PRODUCTION

摘要

The present invention provides humanised antibody molecules (HAMs) having specificity for carcinoembryonic antigen CEA) and having an antigen binding site wherein at least one of the complementarily determining regions (CDRs) of the var- iable domains is derived from the mouse monoclonal antibody A5B7 ( B7 MAb) and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin. The HA may be chimeric humanised antibodies or CDR-graft- ed humanised antibodies and are preferably produced by recombinant DNA techniques. The HAMs are useful for in vivo diag- nosis and therapy.