| 摘要 |
The invention relates to the field of macrolides. It concerns 12-(2'-cyclopentylvinyl)-11,28-dioxa-4-azatricyclo[22.3.1.0<4,9>]octac os-18-ene or -14,18-diene and 11-(2 min -cyclopentylvinyl)-10,27-dioxa-4-azatricyclo[21.3.1.0<4,8>]heptacos-17 -ene or -13,17-diene derivatives, in particular the compounds of formula I <CHEM> wherein the substituents have various significances. They are prepared by a process comprising ring contraction accompanied by appropriate derivatization. They possess interesting pharmacological activity as immunosuppressant and antiproliferative, antiinflammatory, and chemotherapeutic drug resistance reversing agents. |
