PREPARATION OF OPTICALLY ACTIVE ALIPHATIC CARBOXYLIC ACIDS

摘要

CASE PI-6138 PREPARATION OF ALIPHATIC CARBOXYLIC ACIDS A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises i) forming a salt solution comprising said racemic mixture of a C1 to C6 linear or branched aliphatic carboxylic acid and an organic or inorganic base, ii) treating said salt solution with a chiral organic nitrogenous base having a base strength no stronger than said organic or inorganic base, iii) precipitating from the reaction solution formed in step ii) the less soluble diastereomeric salt, and iv) separating saidprecipitated diastereomeric salt.