| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I [R<1> is H, lower alkyl, amino; R<2> is OH, lower alkoxy, -N(R<3>)(R<4>)(R<3> and R<4> are H, lower alkyl, or cyclo alkyl); A is lower alkylene; Z is O, S, N-R<5> (R<5> is H, lower alkyl)]. EXAMPLE:N-Ethyl-N-cyclohexyl-4-( 5-methyl-1,3,4-oxadiazole-2-yl )thio-butylamide. USE:An antiulcer or an antiphlogistic. PROCESS:A compound shown by the formula 4 is reacted with a compound shown by the formula 5 [one of X<1> and X<2> is halogen and the other is mercapto group or -S-C(=NH)(-NH2)] is the presence of a basic condensation agent to give a compound shown by the formula I. A compound shown by the formula 2 is reacted with an amine shown by the formula 3 to give a compound shown by the formula 1 wherein R<2> is -N(R<3>)(R<4>), and the desired substances wherein R<2> are OH and lower alkoxy are interchangeable each other.</p> |
