DIOXO-TETRAHYDROQUINOLINE DERIVATIVES

摘要

T1077Y DIOXO-TETRAXYDROQUINOLINE DERIVATIVES A class of 2,4-dioxo-1,2,3,4-tetrahydro-quinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a fiveor six-membered heteroaromatic moiety, are selective noncompetitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.