| 摘要 |
<p>The invention relates to vaccine compositions capable of blocking cytotoxic activity, particularly cytotoxic activity, with regard to lymphocytes and/or nerve cells, exhibited by retroviral regulatory proteins having basic regions, said composition possibly being capable of also blocking retroviral proliferation characterised in that the active component of said composition is a (poly)peptide composed of: i) at least one basic region, said basic region comprising at least 6 amino acids, at least 4, and preferably at least 5 of any six consecutive amino acids of this region being basic amino acids; ii) optionally a non-basic region or regions wherein ''non-basic'' means less than 4 amino acids of any 6 consecutive amino acids being basic. The invention also relates to antibodies capable of blocking the cytotoxic, activities of retroviral regulatory proteins, and to peptide analogues of the regulatory proteins.</p> |
