MULTIMERIC GELSOLIN FUSION CONSTRUCTS

摘要

This invention relates to multimeric and hetero-multimeric gelsolin fusion constructs, compositions containing them and methods using them. More particularly, this invention relates to multimeric gelsolin fusion constructs in which at least two gelsolin fusion polypeptides are bound to vesicles containing polyphosphoinositides. This invention also relates to gelsolin fusion polypeptides which comprise gelsolin moieties linked to functional moieties and in particular, to CD4-gelsolin fusion polypeptides comprising an amino acid sequence for a human CD4 protein linked to a gelsolin moiety.