发明名称 Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines.
摘要 <p>Antiviral activity is exhibited by compounds having the formula &lt;CHEM&gt; and its pharmaceutically acceptable salts wherein R1 is &lt;CHEM&gt; &lt;CHEM&gt; wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; R3 is fluoro, chloro, bromo, iodo, hydrogen, methyl, trifluoromethyl, ethyl, n-propyl, 2-fluoroethyl, 2-chloroethyl, or &lt;CHEM&gt; wherein R4 is chloro, bromo, iodo, hydrogen, methyl or trifluoromethyl; R5 is alkyl; R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independently hydrogen, &lt;CHEM&gt; </p>
申请公布号 EP0458363(A1) 申请公布日期 1991.11.27
申请号 EP19910108486 申请日期 1991.05.24
申请人 E.R. SQUIBB & SONS, INC. 发明人 ZAHLER, ROBERT;VITE, GREGORY D.;GOODFELLOW, VAL S.;AHMAD, SALEEM
分类号 A61K31/34;A61K31/341;A61K31/357;A61K31/52;A61K31/522;A61P31/12;C07C43/178;C07C43/313;C07C43/315;C07C45/51;C07C45/63;C07C49/753;C07C69/757;C07D239/46;C07D239/47;C07D239/54;C07D239/553;C07D307/33;C07D317/26;C07D473/00;C07D473/16;C07D473/18;C07D473/28;C07D473/40 主分类号 A61K31/34
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