Stabilization of enteric coated dosage form

摘要

The present invention is a stabilized enteric-coated pharmaceutical dosage form and processes for the preparation thereof. Dissolution stability after storage of the dosage form under high stress conditions is improved by an enteric-coated dosage form having an enteric coating wherein the coating is of the acrylic resin kind of from 14 mg/cm2 to 24 mg/cm2 or an enteric coating wherein the coating is of the acetate kind of from 14 mg/cm2 to 24 mg/cm2 and having a second coating of hydrophilic coating for example, hydroxypropyl cellulose, hydroxymethyl cellulose or hydroxypropylmethyl cellulose.