| 摘要 |
<p>There are provided compounds of the formula (I) <CHEM> wherein R7 is a halogen or a C1-C4 alkoxy group; R4 is a substituted alkyl group CHR'-CHR''Y, or an alkenyl group CR'=CHY, wherein R' and R'' each represent, independently, hydrogen or an unsubstituted or substituted C1-C7 straight or branched alkyl, phenyl or benzyl group or R' and R'', taken together with the carbon atoms to which they are attached, form a five membered or six membered ring of the formulae <CHEM> wherein Y is an electron-withdrawing group and A is hydrogen or a carboxy group; R is hydrogen, a C1-C7 straight or branched alkyl, or an unsubstituted or substituted benzyl or diphenylmethyl group; R3 is methyl or a C1-C4 alkoxymethyl group; and R2 is hydrogen or a group R4 as defined above. The compounds of formula (I) are endowed with elastase inhibitory activity, and can be used for the treatment of inflammatory and degenerative diseases. A process for their preparation, and pharmaceutical compositions containing them, are also provided.</p> |
