发明名称 |
LIPOSOMEN MIT ANTHRACYCLINDERIVATEN ENTHALTENDE MITTEL. |
摘要 |
Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of anthracyclines, the 4-demethoxy-3'-desamino-2'-iodo analogs, shown to have extremely high incorporatio efficiencies of greater than 95%. These liposomes demonstrate an improved antitumor efficacy, with much reduced toxicity, against accepted tumor models, and further exhibit excellent stability upon storage, for example, in the form of a dried powder. |
申请公布号 |
AT68964(T) |
申请公布日期 |
1991.11.15 |
申请号 |
AT19880905137T |
申请日期 |
1988.05.18 |
申请人 |
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
PEREZ-SOLER, ROMAN;PRIEBE, WALDEMAR;LOPEZ-BERESTEIN, GABRIEL |
分类号 |
C07H15/252;A61K9/127;A61K31/203;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;(IPC1-7):A61K9/127;A61K31/71 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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