HUMANIZED CHIMERIC ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USE

摘要

2081479 9116928 PCTABS00008 The present invention discloses humanized chimeric antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. Specifically, disclosed are humanized anti-ICAM-1 antibodies of the IgG1, IgG2, and IgG4 subtype. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.