Aromatic heterocyclic derivatives and their thereapeutic and cosmetic use

摘要

An aromatic heterocyclic compound has the formula <IMAGE> wherein R1 represents (i) -CH3, (ii) -CH2OH or (iii) <IMAGE> wherein R3 represents hydrogen, -OR4 wherein R4 represents hydrogen, alkyl having 1-20 carbon atoms, mono- or polyhydroxyalkyl or R3 represents <IMAGE> wherein r'and r'' represent hydrogen or lower alkyl, R2 represents hydrogen or -CH3 and Ar represents <IMAGE> (A) <IMAGE> (B) wherein Z is O or S, <IMAGE> (C) wherein R5 is lower alkyl or <IMAGE> (D) wherein R6 is hydrogen or alkyl having 1-10 carbon atoms and R7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH and X represents oxygen or sulfur, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C wherein R5 is CH3 and (ii) when Y is CH and X represents sulfur Ar is other than A. The compound is useful in the treatment of dermatologic ailments linked to a keratinization disorder.