发明名称 |
ENZYMATIC SYNTHESIS OF SOLUBLE PHOSPHATIDES FROM PHOSPHOLIPIDS |
摘要 |
A method of preparing a soluble monovalent salt of a phosphatidyl ester which comprises reacting a phospholipid with a primary alcohol in the presence of an enzyme catalyst in a divalent cationic buffered solution and a water immiscible non-ether solvent that does not inactivate the enzyme, to form a divalent cationic salt of the phosphatidyl ester, and suspending the product in the presence of a stoichiometric amount of a monovalent cationic salt whose anion forms an insoluble salt with the divalent cation. The use of Centrifugal Partition Chromatography facilitates the enzyme reaction. The monovalent salt is preferably an ammonium/sodium mixed salt.
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申请公布号 |
CA2080907(A1) |
申请公布日期 |
1991.10.18 |
申请号 |
CA19912080907 |
申请日期 |
1991.04.16 |
申请人 |
LIPOSOME COMPANY, INC. (THE) |
发明人 |
TREMBLAY, PAUL A.;MARZIANI, FRANK;TINO, JOHN A.;PILKIEWICZ, FRANK G. |
分类号 |
A61K9/127;C07F9/10;C12P7/64;C12P9/00;C12P13/00;(IPC1-7):C12P13/00;A61K9/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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