Thiazole and imidazole derivatives and antiulcer composition containing same.

摘要

A thiazole or imidazole derivative having the general formula (I): <CHEM> wherein: R<1> and R<2>, which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R<1> and R<2> may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group; A represents a sulfur atom or -NH-; B represents a lower alkoxy group optionally substituted by a halogen atom; a five- or six-membered saturated heterocyclic ring containing one nitrogen or oxygen atom which ring may be optionally substituted; a six-membered saturated heterocyclic ring containing one oxygen atom plus one nitrogen atom; a group -XR<3> where X represents a group -NR<4> wherein R<3> and R<4>, which may be the same or different, each independently represent a lower alkyl group; or a group -NHC(=Y)R<5> where Y represents an oxygen or sulfur atom or a group =NCN or =CHNO2, and R<5> represents a group -NHR<6> or -SR<6> wherein R<6> represents a lower alkyl group optionally substituted by a halogen atom; m is an integer from 1 to 4; and n is an integer from 0 to 2; and their pharmacologically acceptable salts. The compounds has an antiulcerative activity.