发明名称 |
PYRIDINE AND RELATED AZA HETEROCYCLE DERIVATIVES AS CARDIOVASCULAR AGENTS |
摘要 |
Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: <CHEM> wherein R1 or R3 is a moiety of the formula: <CHEM> wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals. |
申请公布号 |
AU7352591(A) |
申请公布日期 |
1991.09.19 |
申请号 |
AU19910073525 |
申请日期 |
1991.03.15 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
ANDREW STEPHEN TOMCUFCIK;WALTER EDWARD MEYER;JOSEPH WILLIAM MARSICO |
分类号 |
A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4427;A61K31/47;A61P9/00;A61P9/10;A61P9/12;C07D213/74;C07D213/78;C07D213/85;C07D215/38;C07D215/48;C07D215/54;C07D401/12;C07D471/04;C07D495/04;C07D521/00 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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