发明名称 IMMUNOSUPPRESSIVE MACROCYCLIC COMPOUNDS
摘要 There are provided compounds of formula (I), wherein R<1> represents H, OH or alkoxy; R<2> represents H; in addition, R<1> and R<2> may together represent a second bond between the carbon atoms to which they are attached; R<3> represents methyl, ethyl, propyl or allyl; R<4> represents H, OH, alkyl, alkoxy, halogen, amino, S-alkyl, NHCHO or NHCO-alkyl; n represents 1 or 2; X represents O, (H, OH), (H, H) or =NH; and Y represents an optionally substituted cyclohexyl or substituted cyclopentyl group; with various provisos. The compounds are useful, inter alia, as immunosuppressive agents.
申请公布号 WO9113889(A1) 申请公布日期 1991.09.19
申请号 WO1991GB00393 申请日期 1991.03.13
申请人 FISONS PLC 发明人 DONALD, DAVID, KEITH;FURBER, MARK;COOPER, MARTIN, EDWARD
分类号 A61K31/40;A61K31/435;A61P37/06;C07D498/18;C07H19/01;(IPC1-7):C07D498/18;A61K31/70;A61K31/445 主分类号 A61K31/40
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