发明名称 |
PROCESS FOR THE PREPARATION OF CASTANOSPERMINE |
摘要 |
Castanospermine (I) is prepared by starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone. Two additional carbons are added to the starting material using ethyl acetate and a strong base and the resulting cyclic hemiketal is subjected to a series of reductions, with intervening removal of protecting groups, to give the castanospermine. A substituted hydroxypyrrolidinone and a substituted hydroxypyrrolidine serve as intermediates in the process. <CHEM> - |
申请公布号 |
AU7264091(A) |
申请公布日期 |
1991.09.12 |
申请号 |
AU19910072640 |
申请日期 |
1991.03.06 |
申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
PETER B. ANZEVENO;PAUL T. ANGELL;LAURA J. CREEMER |
分类号 |
C07D471/04;C07D493/04;C07D493/14 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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