CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS

摘要

Compounds of formula (I), wherein A completes a 5 or 6 membered carbocyclic ring which may be saturated or monounsaturated; Y is an alkylene group of from 1 to 9 carbon atoms; R<1> is H or (C1-C4)alkyl; R and R<4> are H, (C1-C6)alkyl, (C3-C7)cycloalkyl, benzyl, or an alternative biolabile ester-forming group; R<2> is defined to include a range of substituent groups including (C1-C6)alkoxy, (C1-C4)alkoxy-(C1-C6)alkoxy and various substituted-alkyl, amino, substituted amino, aryl and heterocyclyl substituents linked directly or by O, S(O)n, NR<6>, CO or CONR<6> wherein R<6> is H, (C1-C4)alkyl or aryl(C1-C4)alkyl and n is 0, 1 or 2; R<3> is a group of formula (II), wherein R<13> is H, halo, 4-OH, 4-(C1-C6 alkoxy), 4-(C3-C7 cycloalkoxy), 4-(C2-C6 alkenyloxy), 4-[(C1-C6 alkoxy)carbonyloxy], 4-[(C3-C7 cycloalkyloxy)carbonyloxy], or 3-(C1-C4 alkyl)SO2NH-; and R<14> is H, (C1-C4)alkyl, (C1-C4)alkoxy, (C2-C6)alkanoyl or halo; or R<3> is a group of formulae (III) or (IV), wherein said groups may optionally be substituted in the fused benzene ring by (C1-C4)alkyl, (C1-C4)alkoxy, OH, halo or CF3; or are atriopeptidase inhibitors or utility in the treatment of hypertension and heart failure.