摘要 |
The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64 000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum. <IMAGE> |
申请人 |
CENTRO DE INGENIERIA GENETICA Y/BIOTECNOLOGIA |
发明人 |
RODRIGUEZ, RICARDO SILVA;SOSA, MANUEL SELMAN HOUSSEIN;NIETO, GERARDO GUILLEN;MARTINEZ, LUIS SATURNINO HERRERA;MASO, JULIO RAUL FERNANDEZ;PEREZ, LIDIA INES NOVOA;GRILLO, JUAN MORALES;CORDOVA, VIVIAN MORERA;BLANCO, SONIA GONZALEZ;SANTOS, BEATRIZ TAMARGO;VALLE ROSALES, JESUS AUGUSTO DEL;MENENDEZ, EVELIN CABALLERO;ACOSTA, ANABEL ALVAREZ;RODRIGUEZ, EDELGIS COUZEAU;LEON, SILIAN CRUZ;LASA, ALEXIS MUSACCHIO |